Gene

exo1

ID

ZDB-GENE-040426-2828

Name

exonuclease 1

Symbol

exo1 Nomenclature History

Previous Names

fc16e04 (1)
wu:fc16e04 (1)
zgc:55521 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable 5'-flap endonuclease activity and single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human EXO1 (exonuclease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149750 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa17356	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa42919	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With exo1 Human Ortholog

No data available

Associated With exo1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR008918	Helix-hairpin-helix motif, class 2
Conserved_site	IPR019974	XPG conserved site
Domain	IPR006085	XPG, N-terminal
Domain	IPR006086	XPG-I domain
Domain	IPR037315	Exonuclease-1, H3TH domain

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Domain Details Per Protein

Protein	Additional Resources	Length	5'-3' exonuclease, C-terminal domain superfamily	Exonuclease-1, H3TH domain	Exonuclease 1-like, PIN-like domain	Helix-hairpin-helix motif, class 2	PIN-like domain superfamily	Tetratricopeptide repeat	XPG conserved site	XPG-I domain	XPG, N-terminal	XPG/Rad2 endonuclease
UniProtKB:Q803U7	InterPro	806

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	exo1-201 (1) Ensembl	Ensembl	2,735 nt	Select Tool ZFIN BLAST
mRNA	exo1-202 (1) Ensembl	Ensembl	547 nt	Select Tool ZFIN BLAST
mRNA	exo1-203 (1) Ensembl	Ensembl	811 nt	Select Tool ZFIN BLAST
mRNA	exo1-205 (1) Ensembl	Ensembl	5,010 nt	Select Tool ZFIN BLAST
ncRNA	exo1-004 (1) Ensembl	Ensembl	608 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-125O16	BX511245	ZFIN Curated Data
Encodes	EST	fc16e04	AI641503 AI657708
Encodes	EST	IMAGE:7149750	CK686964	Thisse et al., 2004
Encodes	cDNA	MGC:55521	BC044187	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_213469 (1)	2686 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX511245 (2)	96687 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q803U7 (1)	806 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	EXO1	1	Ensembl:ENSG00000174371 Gene:9156 HGNC:3511 OMIM:606063	Amino acid sequence comparison (1)
Mouse	Exo1	1	Ensembl:ENSMUSG00000039748 Gene:26909 MGI:1349427	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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