Gene
aqp3a
- ID
- ZDB-GENE-040426-2826
- Name
- aquaporin 3a
- Symbol
- aqp3a Nomenclature History
- Previous Names
-
- wu:fa95h06
- wu:fi13e05
- zgc:55525 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables several functions, including arsenite transmembrane transporter activity; glycerol transmembrane transporter activity; and water transmembrane transporter activity. Acts upstream of or within late stripe melanocyte differentiation. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including EVL; digestive system; integument; nervous system; and pleuroperitoneal region. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55525 (10 images)
- IMAGE:7152624 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa40535 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tVBU1 | Allele with one point mutation | Unknown | Missense | ENU | |
| tVE1 | Allele with one point mutation | Unknown | Missense | ENU | |
| tWGU2 | Allele with one point mutation | Unknown | Missense | ENU | |
| tXGU1 | Allele with one point mutation | Unknown | Missense | ENU | |
| zf1026 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aqp3a | Eskova et al., 2017 | |
| MO1-aqp3a | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Blood group GIL] | 607457 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aquaporin 3 | Aquaporin-like | Major intrinsic protein | Major Intrinsic Protein/Aquaporin | Major intrinsic protein, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q803U6
|
296 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-245N4 | ZFIN Curated Data | |
| Encodes | EST | fa95h06 | ZFIN Curated Data | |
| Encodes | EST | fi13e05 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7152624 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55525 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191413 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213468 (1) | 1824 nt | ||
| Genomic | GenBank:BX470138 (1) | 117265 nt | ||
| Polypeptide | UniProtKB:Q803U6 (1) | 296 aa |
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Yao, J., Cai, Y., Chen, Z., Wang, X., Lai, X., Pan, L., Li, Y., Wang, S. (2023) DExH/D RNA helicase 15 regulates zebrafish intestinal development through the Wnt signaling pathway. Genomics. 115(2):110578
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Félix, R.C., Anjos, L., Costa, R.A., Letsiou, S., Power, D.M. (2021) Cartilage Acidic Protein a Novel Therapeutic Factor to Improve Skin Damage Repair?. Marine drugs. 19(10):
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Goudarzi, M., Boquet-Pujadas, A., Olivo-Marin, J.C., Raz, E. (2019) Fluid dynamics during bleb formation in migrating cells in vivo. PLoS One. 14:e0212699
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