Gene
uba3
- ID
- ZDB-GENE-040426-2825
- Name
- ubiquitin-like modifier activating enzyme 3
- Symbol
- uba3 Nomenclature History
- Previous Names
-
- ube1c (1)
- wu:fb75e04
- wu:fc37b11
- zgc:55528
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytoplasm and nucleus. Is expressed in inner ear. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55528 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033127 | Ubiquitin-activating enzyme E1, Cys active site |
| Domain | IPR000594 | THIF-type NAD/FAD binding fold |
| Domain | IPR014929 | E2 binding |
| Domain | IPR030468 | NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain |
| Family | IPR045886 | ThiF/MoeB/HesA family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | E2 binding | NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin-activating enzyme | Ubiquitin activating enzyme, alpha domain superfamily | Ubiquitin-activating enzyme E1, Cys active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVX6 | InterPro | 462 | |||||||
| UniProtKB:A0A8M2B283 | InterPro | 449 | |||||||
| UniProtKB:B2GSP4 | InterPro | 462 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-79I1 | ZFIN Curated Data | |
| Encodes | EST | fb75e04 | ||
| Encodes | EST | fc37b11 | ||
| Encodes | cDNA | MGC:55528 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192681 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213467 (1) | 1817 nt | ||
| Genomic | GenBank:BX572634 (1) | 202461 nt | ||
| Polypeptide | UniProtKB:B2GSP4 (1) | 462 aa |
- Liu, S., Hu, G., Luo, S., Wu, W., Zhou, Q., Jin, R., Zhang, Y., Ruan, H., Huang, H., Li, H. (2022) Insights into the evolution of the ISG15 and UBA7 system. Genomics. 114(2):110302
- Shi, H., Wang, H., Yao, J., Lin, C., Wei, Q., Lu, Y., Cao, X. (2019) Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues. Biochemical and Biophysical Research Communications. 521(1):42-49
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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