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Gene

sec23a

ID
ZDB-GENE-040426-2823
Name
Sec23 homolog A, coat complex II component
Symbol
sec23a Nomenclature History
Previous Names
  • cru
  • crusher
  • wu:fc10f08
  • wu:fi15g03
  • zgc:55534
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity and zinc ion binding activity. Acts upstream of or within pectoral fin morphogenesis; protein targeting; and skeletal system development. Predicted to be located in cytosol. Predicted to be extrinsic component of membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including cartilage element; hatching gland; notochord; polster; and tail bud. Used to study craniolenticulosutural dysplasia. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sec23a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniolenticulosutural dysplasia Alliance Craniolenticulosutural dysplasia 607812
Associated With sec23a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006895 Zinc finger, Sec23/Sec24-type
Domain IPR006896 Sec23/Sec24, trunk domain
Domain IPR006900 Sec23/Sec24, helical domain
Domain IPR007123 Gelsolin-like domain
Domain IPR012990 Sec23/Sec24 beta-sandwich
Domain IPR037550 Sec23, C-terminal
Family IPR037364 Protein transport protein Sec23
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily IPR036174 Zinc finger, Sec23/Sec24-type superfamily
Homologous_superfamily IPR036175 Sec23/Sec24 helical domain superfamily
Homologous_superfamily IPR036180 Gelsolin-like domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Domain Details Per Protein
Protein Length ADF-H/Gelsolin-like domain superfamily Gelsolin-like domain Gelsolin-like domain superfamily Protein transport protein Sec23 Sec23, C-terminal Sec23/Sec24 beta-sandwich Sec23/Sec24, helical domain Sec23/Sec24 helical domain superfamily Sec23/Sec24, trunk domain von Willebrand factor A-like domain superfamily Zinc finger, Sec23/Sec24-type Zinc finger, Sec23/Sec24-type superfamily
UniProtKB:B2GSV7 765
UniProtKB:Q7SZE5 765
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations