Gene
arhgdia
- ID
- ZDB-GENE-040426-2816
- Name
- Rho GDP dissociation inhibitor (GDI) alpha
- Symbol
- arhgdia Nomenclature History
- Previous Names
-
- wu:fa96g11
- zgc:55554 (1)
- zgc:77681
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have Rac GTPase binding activity and Rho GDP-dissociation inhibitor activity. Involved in small GTPase mediated signal transduction. Predicted to localize to cytosol and membrane. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Is expressed in retinal ganglion cell layer. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55554 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gee et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 8 | Alliance | Nephrotic syndrome, type 8 | 615244 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nephrotic syndrome | AB + MO1-arhgdia + MO4-tp53 | standard conditions | Gee et al., 2013 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Rho GDP-dissociation inhibitor domain superfamily | Rho protein GDP-dissociation inhibitor |
|---|---|---|---|---|
|
UniProtKB:Q802W6
|
203 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgdia-201
(1)
|
Ensembl | 2,196 nt | ||
| mRNA |
arhgdia-202
(1)
|
Ensembl | 855 nt |
Interactions and Pathways
No data available
Plasmids
No data available