ZFIN ID: ZDB-GENE-040426-2816
Gene Name: Rho GDP dissociation inhibitor (GDI) alpha
Gene Symbol: arhgdia    Nomenclature History

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Previous Names: wu:fa96g11, zgc:55554 (1), zgc:77681

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have Rac GTPase binding activity and Rho GDP-dissociation inhibitor activity. Involved in small GTPase mediated signal transduction. Predicted to localize to the cytosol and membrane. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Is expressed in retinal ganglion cell layer. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha).
Genome Resources: Alliance (1),  Gene:406770 (1),  Ensembl(GRCz11):ENSDARG00000043795 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55554]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010428Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015287Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028959Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-arhgdia
    1
    MO1-arhgdia N/A 1
    MO2-arhgdia N/A 1
    PHENOTYPE
    Data: 2 figures from Gee et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH arhgdia HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nephrotic syndrome type 8 Alliance Nephrotic syndrome, type 8 615244
    DISEASE ASSOCIATED WITH arhgdia VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    nephrotic syndrome AB + MO1-arhgdia + MO4-tp53 standard conditions Gee et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process small GTPase mediated signal transduction (more)
    Cellular Component cytoplasm (more)
    Molecular Function Rho GDP-dissociation inhibitor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000406 Rho protein GDP-dissociation inhibitor
    Homologous_superfamily IPR014756 Immunoglobulin E-set
    Homologous_superfamily IPR024792 Rho GDP-dissociation inhibitor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgdia-201 (1)    Ensembl 2196
    arhgdia-202 (1)    Ensembl 855
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgdia No data available
    MARKER RELATIONSHIPS
    arhgdia Contained in: [BAC] CH211-43F19 (1)
    arhgdia Encodes: [EST] fa96g11 (1)
    [cDNA] MGC:55554 (1), MGC:77681 (1), MGC:191202 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213461 (1) 2213 bp
    Genomic GenBank:CU693479 (1) 145296 bp
    Select Tool
    Polypeptide UniProtKB:Q6P3J2 (1) 203 aa
    Sequence Information (all 20)
    ORTHOLOGY for arhgdia ( Chr: 3 )
    CITATIONS (30)