Gene

arhgdia

ID
ZDB-GENE-040426-2816
Name
Rho GDP dissociation inhibitor (GDI) alpha
Symbol
arhgdia Nomenclature History
Previous Names
  • wu:fa96g11
  • zgc:55554 (1)
  • zgc:77681
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have Rac GTPase binding activity and Rho GDP-dissociation inhibitor activity. Involved in small GTPase mediated signal transduction. Predicted to localize to cytosol and membrane. Is expressed in retinal ganglion cell layer. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Gee et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With arhgdia Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephrotic syndrome type 8 Alliance Nephrotic syndrome, type 8 615244
Associated With arhgdia Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000406 Rho protein GDP-dissociation inhibitor
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR024792 Rho GDP-dissociation inhibitor domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin E-set Rho GDP-dissociation inhibitor domain superfamily Rho protein GDP-dissociation inhibitor
UniProtKB:Q802W6 203
UniProtKB:Q6P3J2 203
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations