Gene
cmtr2
- ID
- ZDB-GENE-040426-2775
- Name
- cap methyltransferase 2
- Symbol
- cmtr2 Nomenclature History
- Previous Names
-
- ftsjd1
- wu:fj48c05
- zgc:55686
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within mRNA processing and methylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR2 (cap methyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2443 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029305Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20930 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002877 | Ribosomal RNA methyltransferase, FtsJ domain |
| Domain | IPR025807 | Adrift-type ribose 2-O-methyltransferase domain |
| Family | IPR050851 | mRNA Cap 2'-O-Ribose Methyltransferase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
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Domain Details Per Protein
| Protein | Length | Adrift-type ribose 2-O-methyltransferase domain | mRNA Cap 2'-O-Ribose Methyltransferase | Ribosomal RNA methyltransferase, FtsJ domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZVS8
|
743 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69E13 | ZFIN Curated Data | |
| Encodes | EST | eu2443 | Thisse et al., 2005 | |
| Encodes | EST | fj48c05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55686 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213433 (1) | 2759 nt | ||
| Genomic | GenBank:BX510349 (1) | 152064 nt | ||
| Polypeptide | UniProtKB:Q7ZVS8 (1) | 743 aa |
- Dix, T., Haussmann, I., Brivio, S., Nallasivan, M., Hadzhiev, Y., Muller, F., Pettitt, J., Müller, B., Soller, M. (2022) CMTr mediated 2`-O-ribose methylation status of cap adjacent-nucleotides across animals. RNA (New York, N.Y.). 28(10):1377-1390
- Wong, Q.W., Sun, M.A., Lau, S.W., Parsania, C., Zhou, S., Zhong, S., Ge, W. (2017) Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Biology of reproduction. 98(1):42-53
- Zhong, Z., Yang, L., Zhang, Y.E., Xue, Y., He, S. (2016) Correlated expression of retrocopies and parental genes in zebrafish. Molecular genetics and genomics : MGG. 291(2):723-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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