Gene
e2f4
- ID
- ZDB-GENE-040426-2773
- Name
- E2F transcription factor 4
- Symbol
- e2f4 Nomenclature History
- Previous Names
-
- fb72f07
- wu:fb72f07 (1)
- wu:fe05f06
- zgc:63815
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adenohypophysis; head; and trunk. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human E2F4 (E2F transcription factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63815 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xie et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-e2f4 | Chong et al., 2018 | |
| CRISPR2-e2f4 | Chong et al., 2018 | |
| CRISPR3-e2f4 | Xie et al., 2020 | |
| MO1-e2f4 | N/A | Ríos et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
| Domain | IPR032198 | E2F transcription factor, CC-MB domain |
| Family | IPR015633 | E2F Family |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | E2F/DP family, winged-helix DNA-binding domain | E2F-DP heterodimerization region | E2F Family | E2F transcription factor, CC-MB domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4ICD5
|
404 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-228B15 | ZFIN Curated Data | |
| Encodes | EST | fb72f07 | ||
| Encodes | EST | fe05f06 | ||
| Encodes | cDNA | MGC:63815 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213432 (1) | 3359 nt | ||
| Genomic | GenBank:FO904859 (1) | 142869 nt | ||
| Polypeptide | UniProtKB:A0A0R4ICD5 (1) | 404 aa |
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Zhou, F., Rayamajhi, D., Ravi, V., Narasimhan, V., Chong, Y.L., Lu, H., Venkatesh, B., Roy, S. (2020) Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Developmental Biology. 465(2):168-177
- Chong, Y.L., Zhang, Y., Zhou, F., Roy, S. (2018) Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Developmental Biology. 443(2):165-172
- Ríos, Y., Melmed, S., Lin, S., and Liu, N.A. (2011) Zebrafish usp39 Mutation Leads to rb1 mRNA Splicing Defect and Pituitary Lineage Expansion. PLoS Genetics. 7(1):e1001271
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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