Gene

vrk1

ID

ZDB-GENE-040426-2709

Name

VRK serine/threonine kinase 1

Symbol

vrk1 Nomenclature History

Previous Names

wu:fe16f06
zgc:56266

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within neural precursor cell proliferation and spermatogenesis. Predicted to be located in Golgi stack. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56266 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vrk1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive distal hereditary motor neuronopathy 10	Alliance	Neuronopathy, distal hereditary motor, autosomal recessive 10	620542
pontocerebellar hypoplasia type 1A	Alliance	Pontocerebellar hypoplasia type 1A	607596

Associated With vrk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050235	Casein Kinase 1 Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily