Gene

hnrnpl2

ID

ZDB-GENE-040426-2707

Name

heterogeneous nuclear ribonucleoprotein L2

Symbol

hnrnpl2 Nomenclature History

Previous Names

hnrnpl
hnrpl (1)
fb53f10
fp61c04
wu:fb53f10
wu:fp61c04
zgc:66175

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable mRNA binding activity. Acts upstream of or within regulation of skeletal muscle fiber development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66175 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Alexander et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hnrnpl2 Human Ortholog

No data available

Associated With hnrnpl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR021790	PTBP1-like, RNA recognition motif 2
Domain	IPR034816	hnRNP-L, RNA recognition motif 3
Domain	IPR035005	hnRNP-L, RNA recognition motif 1
Domain	IPR035008	hnRNP-L, RNA recognition motif 2
Family	IPR006536	HnRNP-L/PTB
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	HnRNP-L/PTB	hnRNP-L, RNA recognition motif 1	hnRNP-L, RNA recognition motif 2	hnRNP-L, RNA recognition motif 3	Nucleotide-binding alpha-beta plait domain superfamily	PTBP1-like, RNA recognition motif 2	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:A0A0R4IVC0 InterPro	499
UniProtKB:A0A8M3ASF7 InterPro	288
UniProtKB:A8KC22 InterPro	522
UniProtKB:Q7SYM9 InterPro	481
UniProtKB:A0A8M6Z0P8 InterPro	265

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hnrnpl2-204 (1) Ensembl	Ensembl	829 nt	Select Tool ZFIN BLAST
mRNA	hnrnpl2-202 (1) Ensembl	Ensembl	1,592 nt	Select Tool ZFIN BLAST
mRNA	hnrnpl2-205 (1) Ensembl	Ensembl	2,064 nt	Select Tool ZFIN BLAST
ncRNA	hnrnpl2-003 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST
ncRNA	hnrnpl2-004 (1) Ensembl	Ensembl	636 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations