Gene
oclna
- ID
- ZDB-GENE-040426-2685
- Name
- occludin a
- Symbol
- oclna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to be involved in bicellular tight junction assembly. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including EVL; digestive system; musculature system; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56359 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pseudo-TORCH syndrome 1 | Alliance | Pseudo-TORCH syndrome 1 | 251290 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ELL/occludin family | Marvel domain | Occludin | Occludin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:F1R799 | InterPro | 491 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24N17 | ZFIN Curated Data | |
| Encodes | EST | fd23h10 | ||
| Encodes | EST | fi13c01 | ||
| Encodes | cDNA | MGC:56359 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113992 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212832 (1) | 2205 nt | ||
| Genomic | GenBank:CR394525 (1) | 215862 nt | ||
| Polypeptide | UniProtKB:F1R799 (1) | 491 aa |
- Brychka, D., Ayala-Nunez, N.V., Dupas, A., Bare, Y., Partiot, E., Mittelheisser, V., Lucansky, V., Goetz, J.G., Osmani, N., Gaudin, R. (2024) Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion. EMBO reports. 25(8):3276-3299
- Yan, J., Fang, L., Ni, A., Xi, M., Li, J., Zhou, X., Qian, Q., Wang, Z.J., Wang, X., Wang, H. (2024) Long-Term Neurotoxic Effects and Alzheimer's Disease Risk of Early EHDPP Exposure in Zebrafish: Insights from Molecular Mechanisms to Adult Pathology. Environmental science & technology. 58(43):19152-19164
- Liu, Y., Zhu, D., Liu, J., Sun, X., Gao, F., Duan, H., Dong, L., Wang, X., Wu, C. (2023) Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Frontiers in nutrition. 10:10877031087703
- Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822
- Ding, Q., Zhang, Z., Li, Y., Liu, H., Hao, Q., Yang, Y., Ringø, E., Olsen, R.E., Clarke, J.L., Ran, C., Zhou, Z. (2021) Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. iScience. 24:102515
- Phatak, M., Kulkarni, S., Miles, L.B., Anjum, N., Dworkin, S., Sonawane, M. (2021) Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish. PLoS Genetics. 17:e1009823
- Sharma, S., Kumar, M., Kumar, J., Srivastava, N., Hussain, M.A., Shelly, A., Mazumder, S. (2021) M. fortuitum-induced CNS-pathology: Deciphering the role of canonical Wnt signaling, blood brain barrier components and cytokines. Developmental and comparative immunology. 122:104111
- Zhang, F.L., Yang, Y.L., Zhang, Z., Yao, Y.Y., Xia, R., Gao, C.C., Du, D.D., Hu, J., Ran, C., Liu, Z., Zhou, Z.G. (2021) Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Frontiers in nutrition. 8:726108
- Chen, Z., Zhijie, C., Yuting, Z., Shilin, X., Qichun, Z., Jinying, O., Chaohua, L., Jing, L., Zhixian, M. (2020) Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Frontiers in microbiology. 11:946
- Das, T., Soren, K., Yerasi, M., Kumar, A., Chakravarty, S. (2019) Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model. Neuroscience letters. 712:134492
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