Gene

mre11a

ID
ZDB-GENE-040426-2638
Name
MRE11 homolog A, double strand break repair nuclease
Symbol
mre11a Nomenclature History
Previous Names
  • fc38f05
  • wu:faa63d12
  • wu:fc38f05
  • zgc:64018
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have 3'-5'-exodeoxyribonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in mitotic DNA damage checkpoint and nucleic acid metabolic process. Predicted to colocalize with nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mre11a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ataxia-telangiectasia-like disorder 1 604391
Associated With mre11a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
Domain IPR007281 Mre11, DNA-binding
Domain IPR041796 Mre11 nuclease, N-terminal metallophosphatase domain
Family IPR003701 DNA double-strand break repair protein Mre11
Homologous_superfamily IPR029052 Metallo-dependent phosphatase-like
Homologous_superfamily IPR038487 Mre11, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Calcineurin-like phosphoesterase domain, ApaH type DNA double-strand break repair protein Mre11 Metallo-dependent phosphatase-like Mre11, DNA-binding Mre11, DNA-binding domain superfamily Mre11 nuclease, N-terminal metallophosphatase domain
UniProtKB:A0A0R4ITV5 700
UniProtKB:A0A0R4IMM7 619
UniProtKB:Q7T397 619
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations