Gene

nnt

ID

ZDB-GENE-040426-2592

Name

nicotinamide nucleotide transhydrogenase

Symbol

nnt Nomenclature History

Previous Names

wu:fa20d10
wu:fc86a04
zgc:76979

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in NADPH regeneration. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Is expressed in female organism. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

IMAGE:6912632 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nnt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency	614736

Associated With nnt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR008142	Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1
Domain	IPR007698	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
Domain	IPR007886	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
Domain	IPR024605	NAD(P) transhydrogenase, alpha subunit, C-terminal
Domain	IPR034300	NADP transhydrogenase beta-like domain
Family	IPR026255	NAD(P) transhydrogenase, alpha subunit
Homologous_superfamily	IPR029035	DHS-like NAD/FAD-binding domain superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily