Gene
nnt
- ID
- ZDB-GENE-040426-2592
- Name
- nicotinamide nucleotide transhydrogenase
- Symbol
- nnt Nomenclature History
- Previous Names
-
- wu:fa20d10
- wu:fc86a04
- zgc:76979
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable NADP binding activity. Acts upstream of or within regulation of pigmentation. Predicted to be located in mitochondrial inner membrane. Is expressed in female organism. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912632 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Mazumdar et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency | 614736 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008142 | Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 |
| Domain | IPR007698 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain |
| Domain | IPR007886 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal |
| Domain | IPR024605 | NAD(P) transhydrogenase, alpha subunit, C-terminal |
| Domain | IPR034300 | NADP transhydrogenase beta-like domain |
| Family | IPR026255 | NAD(P) transhydrogenase, alpha subunit |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal | DHS-like NAD/FAD-binding domain superfamily | NAD(P)-binding domain superfamily | NAD(P) transhydrogenase, alpha subunit | NAD(P) transhydrogenase, alpha subunit, C-terminal | NADP transhydrogenase beta-like domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYQ7 | InterPro | 1079 |
Interactions and Pathways
No data available
Plasmids
No data available