Gene
nnt
- ID
- ZDB-GENE-040426-2592
- Name
- nicotinamide nucleotide transhydrogenase
- Symbol
- nnt Nomenclature History
- Previous Names
-
- wu:fa20d10
- wu:fc86a04
- zgc:76979
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable NADP binding activity. Acts upstream of or within regulation of pigmentation. Predicted to be located in mitochondrial inner membrane. Is expressed in female organism. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912632 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Mazumdar et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nnt | Allouche et al., 2021 | |
| CRISPR2-nnt | Allouche et al., 2021 | |
| CRISPR3-nnt | Allouche et al., 2021 | |
| CRISPR4-nnt | Mazumdar et al., 2023 | |
| MO1-nnt | N/A | Bainbridge et al., 2015 |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency | 614736 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008142 | Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 |
| Domain | IPR007698 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain |
| Domain | IPR007886 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal |
| Domain | IPR024605 | NAD(P) transhydrogenase, alpha subunit, C-terminal |
| Domain | IPR034300 | NADP transhydrogenase beta-like domain |
1 - 5 of 8 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal | DHS-like NAD/FAD-binding domain superfamily | NAD(P)-binding domain superfamily | NAD(P) transhydrogenase, alpha subunit | NAD(P) transhydrogenase, alpha subunit, C-terminal | NADP transhydrogenase beta-like domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYQ7 | InterPro | 1079 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147J13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-284A17 | ZFIN Curated Data | |
| Encodes | EST | fa20d10 | ZFIN Curated Data | |
| Encodes | EST | fc86a04 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6912632 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:76979 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174430 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214756 (1) | 4750 nt | ||
| Genomic | GenBank:BX927162 (1) | 90057 nt | ||
| Polypeptide | UniProtKB:Q6NYQ7 (1) | 1079 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | NNT | 5 | Amino acid sequence comparison (1) |
- Mazumdar, R., Eberhart, J.K. (2023) Loss of Nicotinamide nucleotide transhydrogenase sensitizes embryos to ethanol-induced neural crest and neural apoptosis via generation of reactive oxygen species. Frontiers in neuroscience. 17:11546211154621
- Allouche, J., Rachmin, I., Adhikari, K., Pardo, L.M., Lee, J.H., McConnell, A.M., Kato, S., Fan, S., Kawakami, A., Suita, Y., Wakamatsu, K., Igras, V., Zhang, J., Navarro, P.P., Lugo, C.M., Noonan, H.R., Christie, K.A., Itin, K., Mujahid, N., Lo, J.A., Won, C.H., Evans, C.L., Weng, Q.Y., Wang, H., Osseiran, S., Lovas, A., Németh, I., Cozzio, A., Navarini, A.A., Hsiao, J.J., Nguyen, N., Kemény, L.V., Iliopoulos, O., Berking, C., Ruzicka, T., Gonzalez-José, R., Bortolini, M.C., Canizales-Quinteros, S., Acuna-Alonso, V., Gallo, C., Poletti, G., Bedoya, G., Rothhammer, F., Ito, S., Schiaffino, M.V., Chao, L.H., Kleinstiver, B.P., Tishkoff, S., Zon, L.I., Nijsten, T., Ruiz-Linares, A., Fisher, D.E., Roider, E. (2021) NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 184(16):4268-4283.e20
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Holowiecki, A., O'Shields, B., Jenny, M.J. (2017) Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 191:138-151
- Bainbridge, M.N., Davis, E.E., Choi, W.Y., Dickson, A., Martinez, H.R., Wang, M., Dinh, H., Muzny, D., Pignatelli, R., Katsanis, N., Boerwinkle, E., Gibbs, R., Jefferies, J.L. (2015) Loss of Function Mutations in NNT Are Associated with Left Ventricular Noncompaction. Circulation. Cardiovascular genetics. 8(4):544-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
1 - 10 of 11
Show