Gene
irf2bp2b
- ID
- ZDB-GENE-040426-2574
- Name
- interferon regulatory factor 2 binding protein 2b
- Symbol
- irf2bp2b Nomenclature History
- Previous Names
-
- irf2bp2
- wu:fa12b04
- wu:fb73g01
- zgc:63864
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and molecular function inhibitor activity. Involved in negative regulation of macrophage differentiation. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; musculature system; nervous system; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63864 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 14 | Alliance | ?Immunodeficiency, common variable, 14 | 617765 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily | Interferon regulatory factor 2-binding protein 1 & 2, zinc finger |
|---|---|---|---|
|
UniProtKB:Q7T2G1
|
501 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
irf2bp2b-201
(1)
|
Ensembl | 2,117 nt |
Interactions and Pathways
No data available
Plasmids
No data available