Gene
arhgap11a
- ID
- ZDB-GENE-040426-2562
- Name
- Rho GTPase activating protein 11A
- Symbol
- arhgap11a Nomenclature History
- Previous Names
-
- wu:fc02e04
- wu:fc55g06
- wu:fe01b01
- zgc:77004
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Orthologous to human ARHGAP11A (Rho GTPase activating protein 11A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77004 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Rho GTPase-activating protein 11 | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|
| UniProtKB:A0A0R4ILK3 | InterPro | 890 | |||
| UniProtKB:A0A8M2BKT8 | InterPro | 865 | |||
| UniProtKB:A0A0R4IMZ9 | InterPro | 461 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap11a-201
(1)
|
Ensembl | 2,360 nt | ||
| mRNA |
arhgap11a-202
(1)
|
Ensembl | 853 nt | ||
| mRNA |
arhgap11a-204
(1)
|
Ensembl | 3,882 nt | ||
| ncRNA |
arhgap11a-003
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-381J11 | ||
| Contains | SNP | rs3728824 | ZFIN Curated Data | |
| Encodes | EST | fc02e04 | ||
| Encodes | EST | fc55g06 | ||
| Encodes | EST | fe01b01 | ||
| Encodes | EST | wz12850 | ||
| Encodes | cDNA | MGC:77004 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001193539 (1) | 3874 nt | ||
| Genomic | GenBank:CU655844 (2) | 42318 nt | ||
| Polypeptide | UniProtKB:A0A0R4ILK3 (1) | 890 aa |
- Insco, M.L., Abraham, B.J., Dubbury, S.J., Kaltheuner, I.H., Dust, S., Wu, C., Chen, K.Y., Liu, D., Bellaousov, S., Cox, A.M., Martin, B.J.E., Zhang, T., Ludwig, C.G., Fabo, T., Modhurima, R., Esgdaille, D.E., Henriques, T., Brown, K.M., Chanock, S.J., Geyer, M., Adelman, K., Sharp, P.A., Young, R.A., Boutz, P.L., Zon, L.I. (2023) Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.). 380:eabn7625eabn7625
- Ablain, J., Al Mahi, A., Rothschild, H., Prasad, M., Aires, S., Yang, S., Dokukin, M.E., Xu, S., Dang, M., Sokolov, I., Lian, C.G., Zon, L.I. (2022) Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nature Genetics. 54(12):1839-1852
- Uribe-Salazar, J.M., Kaya, G., Sekar, A., Weyenberg, K., Ingamells, C., Dennis, M.Y. (2022) Evaluation of CRISPR gene-editing tools in zebrafish. BMC Genomics. 23:12
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Sztal, T.E., McKaige, E.A., Williams, C., Ruparelia, A.A., Bryson-Richardson, R.J. (2018) Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. PLoS Genetics. 14:e1007212
- Maddison, L.A., Lu, J., Victoroff, T., Scott, E., Baier, H., and Chen, W. (2009) A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Molecular genetics and genomics : MGG. 281(5):551-563
- Ferg, M., Sanges, R., Gehrig, J., Kiss, J., Bauer, M., Lovas, A., Szabo, M., Yang, L., Straehle, U., Pankratz, M.J., Olasz, F., Stupka, E., and Müller, F. (2007) The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. The EMBO journal. 26(17):3945-3956
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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