Gene

egln3

ID

ZDB-GENE-040426-2541

Name

egl-9 family hypoxia-inducible factor 3

Symbol

egln3 Nomenclature History

Previous Names

Hif-p4h-3 (1)
phd3 (1)
wu:fj78a08
zgc:77019

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have L-ascorbic acid binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is expressed in axial mesoderm; liver; margin; and neural plate. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907425 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With egln3 Human Ortholog

No data available

Associated With egln3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR044862	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Family	IPR051559	Hypoxia-inducible factor prolyl hydroxylases