Gene

pik3cg

ID
ZDB-GENE-040426-2532
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Symbol
pik3cg Nomenclature History
Previous Names
  • wu:fb15d07
  • zgc:77033
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within neutrophil chemotaxis. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3cg Human Ortholog
No data available
Associated With pik3cg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
Domain IPR002420 Phosphatidylinositol 3-kinase, C2 domain
Domain IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
Family IPR015433 Phosphatidylinositol kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain Phosphatidylinositol 3-kinase, C2 domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Phosphatidylinositol kinase Phosphoinositide 3-kinase, accessory (PIK) domain Phosphoinositide 3-kinase, accessory (PIK) domain superfamily Protein kinase-like domain superfamily Ubiquitin-like domain superfamily
UniProtKB:F1QVE6 1098
UniProtKB:Q6NTI2 1098
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations