Gene
dpydb
- ID
- ZDB-GENE-040426-2459
- Name
- dihydropyrimidine dehydrogenase b
- Symbol
- dpydb Nomenclature History
- Previous Names
-
- dpyd
- zgc:77205 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have several functions, including NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77205 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dihydropyrimidine dehydrogenase deficiency | Alliance | 5-fluorouracil toxicity | 274270 |
| dihydropyrimidine dehydrogenase deficiency | Alliance | Dihydropyrimidine dehydrogenase deficiency | 274270 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| Domain | IPR005720 | Dihydroorotate dehydrogenase, catalytic |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR028261 | Dihydroprymidine dehydrogenase domain II |
| Homologous_superfamily | IPR009051 | Alpha-helical ferredoxin |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Aldolase-type TIM barrel | Alpha-helical ferredoxin | Dihydroorotate dehydrogenase, catalytic | Dihydroprymidine dehydrogenase domain II | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NYG8
|
1022 |
Interactions and Pathways
No data available
Plasmids
No data available