Gene
anp32e
- ID
- ZDB-GENE-040426-2448
- Name
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
- Symbol
- anp32e Nomenclature History
- Previous Names
-
- wu:fb22e03
- wu:fc04c12
- wu:fc19a08
- wu:fc79f04
- wu:fi39c10
- zgc:65995 (1)
- zgc:85827
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity; histone chaperone activity; and phosphatase inhibitor activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within chromatin organization. Predicted to be located in cytoplasm. Predicted to be part of Swr1 complex. Predicted to be active in nucleus. Orthologous to human ANP32E (acidic nuclear phosphoprotein 32 family member E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a231 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la013501Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 2 of 2
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-anp32e | Thyme et al., 2019 | |
| CRISPR2-anp32e | Thyme et al., 2019 | |
| CRISPR3-anp32e | Thyme et al., 2019 | |
| CRISPR4-anp32e | Thyme et al., 2019 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acidic leucine-rich nuclear phosphoprotein 32 | Leucine-rich repeat | Leucine-rich repeat domain superfamily | U2A'/phosphoprotein 32 family A, C-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NUW5 | InterPro | 250 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anp32e-201
(1)
|
Ensembl | 2,456 nt | ||
| mRNA |
anp32e-202
(1)
|
Ensembl | 805 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-200H23 | ZFIN Curated Data | |
| Contains | SNP | rs3728992 | ZFIN Curated Data | |
| Encodes | EST | fb22e03 | ||
| Encodes | EST | fc04c12 | ||
| Encodes | EST | fc19a08 | ||
| Encodes | EST | fc79f04 | ||
| Encodes | EST | fi39c10 | ||
| Encodes | cDNA | MGC:65995 | ||
| Encodes | cDNA | MGC:85827 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113940 | ZFIN Curated Data |
1 - 10 of 10
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213277 (1) | 2486 nt | ||
| Genomic | GenBank:BX571688 (1) | 181466 nt | ||
| Polypeptide | UniProtKB:Q6NUW5 (1) | 250 aa |
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Murphy, P.J., Wu, S.F., James, C.R., Wike, C.L., Cairns, B.R. (2018) Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell. 172(5):993-1006.e13
- Frøyset, A.K., Khan, E.A., Fladmark, K.E. (2016) Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific Reports. 6:29631
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show