Gene

loxa

ID
ZDB-GENE-040426-2398
Name
lysyl oxidase a
Symbol
loxa Nomenclature History
Previous Names
  • lox
  • zgc:77447 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have protein-lysine 6-oxidase activity. Involved in cartilage development; muscle organ development; and neurogenesis. Predicted to localize to extracellular space. Is expressed in brain; head; muscle; notochord; and pectoral fin. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Reynaud et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With loxa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Aortic aneurysm, familial thoracic 10 617168
Associated With loxa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019828 Lysyl oxidase, conserved site
Family IPR001695 Lysyl oxidase
Domain Details Per Protein
Protein Length Lysyl oxidase Lysyl oxidase, conserved site
UniProtKB:A9JTE8 408
UniProtKB:F1QXL0 407
UniProtKB:Q2PS18 407
UniProtKB:Q6NYT8 408
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations