Gene
slc25a25a
- ID
- ZDB-GENE-040426-2396
- Name
- solute carrier family 25 member 25a
- Symbol
- slc25a25a Nomenclature History
- Previous Names
-
- slc25a25
- wu:fb13d12
- wu:fd14e03
- zgc:77454
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in ADP transport and ATP transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in brain; head; inner ear; and somite. Orthologous to human SLC25A25 (solute carrier family 25 member 25).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002048 | EF-hand domain |
| Family | IPR002067 | Mitochondrial carrier protein |
| Family | IPR002167 | Solute carrier family 25 member 16-like |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR023395 | Mitochondrial carrier domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EF-hand domain | EF-hand domain pair | Mitochondrial carrier domain superfamily | Mitochondrial carrier protein | Mitochondrial substrate/solute carrier | Solute carrier family 25 member 16-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYZ6 | InterPro | 469 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc25a25a-201
(1)
|
Ensembl | 2,838 nt | ||
| ncRNA |
slc25a25a-002
(1)
|
Ensembl | 857 nt | ||
| ncRNA |
slc25a25a-003
(1)
|
Ensembl | 542 nt | ||
| ncRNA |
slc25a25a-004
(1)
|
Ensembl | 853 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51H9 | ZFIN Curated Data | |
| Contains | SNP | rs3728128 | ZFIN Curated Data | |
| Contains | SNP | rs3728129 | ZFIN Curated Data | |
| Contains | SNP | rs3728130 | ZFIN Curated Data | |
| Encodes | EST | fb13d12 | ZFIN Curated Data | |
| Encodes | EST | fd14e03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77454 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213257 (1) | 2702 nt | ||
| Genomic | GenBank:BX088526 (1) | 187161 nt | ||
| Polypeptide | UniProtKB:Q6NYZ6 (1) | 469 aa |
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Zhang, X., Xia, M., Su, X., Yuan, P., Li, X., Zhou, C., Wan, Z., Zou, W. (2021) Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis. Journal of hazardous materials. 413:125321
- Calvello, R., Cianciulli, A., Mitolo, V., Porro, A., Panaro, M.A. (2019) Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute Carrier Genes (Zebrafish, Chicken, Mouse and Human). Non-coding RNA. 5(1)
- Hofherr, A., Seger, C., Fitzpatrick, F., Busch, T., Michel, E., Luan, J., Osterried, L., Linden, F., Kramer-Zucker, A., Wakimoto, B., Schütze, C., Wiedemann, N., Artati, A., Adamski, J., Walz, G., Kunji, E.R.S., Montell, C., Watnick, T., Köttgen, M. (2018) The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. PLoS Biology. 16:e2005651
- Xu, H., Liu, X., Jia, Y., Dong, F., Xu, J., Wu, X., Yang, Y., Zheng, Y. (2018) Fipronil-induced toxic effects in zebrafish (Danio rerio) larvae by using digital gene expression profiling. The Science of the total environment. 639:550-559
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
- Jacob, A.E., Turner, C.E., Amack, J.D. (2016) Evolution and Expression of Paxillin Genes in Teleost Fish. PLoS One. 11:e0165266
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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