Gene
leg1.2
- ID
- ZDB-GENE-040426-2281
- Name
- liver-enriched gene 1, tandem duplicate 2
- Symbol
- leg1.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Acts upstream of or within digestive system development and liver development. Located in extracellular space. Is expressed in liver and yolk syncytial layer. Orthologous to human C6orf58 (chromosome 6 open reading frame 58).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77778 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chang et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-leg1.1,leg1.2 | (2) | |
| MO1-leg1.1,leg1.2 | N/A | (2) |
| MO1-leg1.2 | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR008499 | Leg1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Leg1 |
|---|---|---|---|
| UniProtKB:Q4QRF7 | InterPro | 364 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
leg1.2-201
(1)
|
Ensembl | 1,383 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-205N18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77778 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113937 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213203 (1) | 1242 nt | ||
| Genomic | GenBank:AL954182 (1) | 152215 nt | ||
| Polypeptide | UniProtKB:Q4QRF7 (1) | 364 aa |
- Comparative Orthology
- Alliance
- Xie, A., Ma, Z., Wang, J., Zhang, Y., Chen, Y., Yang, C., Chen, J., Peng, J. (2023) Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. Cell discovery. 9:6363
- Wang, J., Bai, Y., Xie, A., Huang, H., Hu, M., Peng, J. (2021) Difference in an intermolecular disulfide-bond between two highly homologous serum proteins Leg1a and Leg1b implicates their functional differentiation. Biochemical and Biophysical Research Communications. 579:81-88
- Dang, Y., Wang, J.Y., Liu, C., Zhang, K., Jinrong, P., He, J. (2020) Evolutionary and Molecular Characterization of liver-enriched gene 1. Scientific Reports. 10:4262
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hu, M., Bai, Y., Zhang, C., Liu, F., Cui, Z., Chen, J., Peng, J. (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genetics. 12:e1005881
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Driessen, M., Kienhuis, A.S., Vitins, A.P., Pennings, J.L., Pronk, T.E., Brandhof, E.J., Roodbergen, M., Water, B.V., Ven, L.T. (2014) Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicology letters. 230(1):48-56
- Lin, T.Y., Chou, C.F., Chung, H.Y., Chiang, C.Y., Li, C.H., Wu, J.L., Lin, H.J., Pai, T.W., Hu, C.H., Tzou, W.S. (2014) Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo. PLoS One. 9:e101980
- Babaei, F., Ramalingam, R., Tavendale, A., Liang, Y., Yan, L.S., Ajuh, P., Cheng, S.H., and Lam, Y.W. (2013) Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish. Journal of Proteome Research. 12(4):1580-90
- Chang, C., Hu, M., Zhu, Z., Lo, L.J., Chen, J., and Peng, J. (2011) liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish. PLoS One. 6(8):e22910
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