Gene

gnb3b

ID

ZDB-GENE-040426-2280

Name

guanine nucleotide binding protein (G protein), beta polypeptide 3b

Symbol

gnb3b Nomenclature History

Previous Names

gnb3
wu:fk54b04
zgc:73058 (1)
zgc:77780

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Is expressed in epiphysis; eye; pineal complex; retina; and retinal cone cell. Orthologous to human GNB3 (G protein subunit beta 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73058 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnb3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital stationary night blindness 1H	Alliance	Night blindness, congenital stationary, type 1H	617024
essential hypertension	Alliance	{Hypertension, essential, susceptibility to}	145500

Associated With gnb3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001632	G-protein, beta subunit
Family	IPR016346	Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	G-protein, beta subunit	G-protein beta WD-40 repeat	Guanine nucleotide-binding protein, beta subunit	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6P025 InterPro	338

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gnb3b-201 (1) Ensembl	Ensembl	2,054 nt	Select Tool ZFIN BLAST
mRNA	gnb3b-202 (1) Ensembl	Ensembl	1,923 nt	Select Tool ZFIN BLAST
mRNA	gnb3b-205 (1) Ensembl	Ensembl	740 nt	Select Tool ZFIN BLAST
ncRNA	gnb3b-004 (1) Ensembl	Ensembl	860 nt	Select Tool ZFIN BLAST
ncRNA	gnb3b-005 (1) Ensembl	Ensembl	428 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations