Gene

gnb3b

ID
ZDB-GENE-040426-2280
Name
guanine nucleotide binding protein (G protein), beta polypeptide 3b
Symbol
gnb3b Nomenclature History
Previous Names
  • gnb3
  • wu:fk54b04
  • zgc:73058 (1)
  • zgc:77780
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; pineal complex; retina; and retinal cone cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnb3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital stationary night blindness 1H Alliance Night blindness, congenital stationary, type 1H 617024
essential hypertension Alliance {Hypertension, essential, susceptibility to} 145500
Associated With gnb3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR001632 G-protein, beta subunit
Domain IPR017986 WD40-repeat-containing domain
Family IPR016346 Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length G-protein, beta subunit G-protein beta WD-40 repeat Guanine nucleotide-binding protein, beta subunit WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6P025 338
UniProtKB:I3ISK4 141
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations