Gene
tnfrsf1a
- ID
- ZDB-GENE-040426-2252
- Name
- tumor necrosis factor receptor superfamily, member 1a
- Symbol
- tnfrsf1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable tumor necrosis factor binding activity and tumor necrosis factor receptor activity. Acts upstream of or within several processes, including defense response to other organism; fin regeneration; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in membrane raft and mitochondrion. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85914 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Troll et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| TNF receptor–associated periodic syndrome | Alliance | Periodic fever, familial | 142680 |
| {Multiple sclerosis, susceptibility to, 5} | 614810 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR033994 | Tumor necrosis factor receptor 1A, death domain |
| Domain | IPR033995 | Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost |
| Family | IPR052493 | Tumor necrosis factor receptor superfamily member 1A |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Death domain | Death-like domain superfamily | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 1A, death domain | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NUU6
|
389 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf1a-201
(1)
|
Ensembl | 2,509 nt | ||
| mRNA |
tnfrsf1a-202
(1)
|
Ensembl | 4,373 nt |
Interactions and Pathways
No data available
Plasmids
No data available