ZFIN is now using GRCz12tu for Genomic Data
Gene
tnfrsf1a
- ID
- ZDB-GENE-040426-2252
- Name
- tumor necrosis factor receptor superfamily, member 1a
- Symbol
- tnfrsf1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable tumor necrosis factor binding activity and tumor necrosis factor receptor activity. Acts upstream of or within several processes, including fin regeneration; neutrophil chemotaxis; and regulation of granuloma formation. Predicted to be part of receptor complex. Predicted to be active in membrane raft. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; TNF receptor–associated periodic syndrome; acne; allergic bronchopulmonary aspergillosis; and rheumatoid arthritis. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85914 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Troll et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| TNF receptor–associated periodic syndrome | Alliance | Periodic fever, familial | 142680 |
| {Multiple sclerosis, susceptibility to, 5} | 614810 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000488 | Death domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR033994 | Tumor necrosis factor receptor 1A, death domain |
| Domain | IPR033995 | Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost |
| Family | IPR052493 | Tumor necrosis factor receptor superfamily member 1A |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor 1A, death domain | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, N-terminal, teleost |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NUU6 | InterPro | 389 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf1a-201
(1)
|
Ensembl | 2,509 nt | ||
| mRNA |
tnfrsf1a-202
(1)
|
Ensembl | 4,373 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers