Gene
slc37a4a
- ID
- ZDB-GENE-040426-2230
- Name
- solute carrier family 37 member 4a
- Symbol
- slc37a4a Nomenclature History
- Previous Names
-
- slc37a4
- fc25d06
- wu:fc25d06
- zgc:77098
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Acts upstream of or within response to steroid hormone. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in intestinal bulb; liver; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77098 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42494 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation type IIw | Alliance | Congenital disorder of glycosylation, type IIw | 619525 |
| glycogen storage disease Ib | Alliance | Glycogen storage disease Ib | 232220 |
| glycogen storage disease Ic | Alliance | Glycogen storage disease Ic | 232240 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR021159 | Glycerate/sugar phosphate transporter, conserved site |
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR000849 | Sugar phosphate transporter |
| Family | IPR011701 | Major facilitator superfamily |
| Family | IPR051337 | Organophosphate:Pi Antiporter |
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Domain Details Per Protein
| Protein | Length | Glycerate/sugar phosphate transporter, conserved site | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily | Organophosphate:Pi Antiporter | Sugar phosphate transporter |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NY67
|
429 | ||||||
|
UniProtKB:A0A8M3AH42
|
429 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc37a4a-201
(1)
|
Ensembl | 1,927 nt | ||
| mRNA |
slc37a4a-202
(1)
|
Ensembl | 317 nt | ||
| mRNA |
slc37a4a-203
(1)
|
Ensembl | 783 nt | ||
| ncRNA |
slc37a4a-004
(1)
|
Ensembl | 773 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-261A10 | ZFIN Curated Data | |
| Encodes | EST | fc25d06 | ||
| Encodes | cDNA | MGC:77098 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214738 (1) | 1417 nt | ||
| Genomic | GenBank:BX927291 (1) | 154479 nt | ||
| Polypeptide | UniProtKB:A0A8M3AH42 (1) | 429 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Klangnurak, W., Tokumoto, T. (2017) Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish.. Zoological letters. 3:2
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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