Gene
nfkbiaa
- ID
- ZDB-GENE-040426-2227
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
- Symbol
- nfkbiaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable NF-kappaB binding activity. Acts upstream of or within negative regulation of hematopoietic progenitor cell differentiation and response to virus. Predicted to be active in cytosol. Is expressed in several structures, including lateral line system; periderm; pronephric duct; tail bud; and vent. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85769 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia and immunodeficiency 2 | Alliance | Ectodermal dysplasia and immunodeficiency 2 | 612132 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | NF-kappa-B Inhibitor |
|---|---|---|---|---|
|
UniProtKB:F1QCG4
|
310 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfkbiaa-202
(1)
|
Ensembl | 1,344 nt | ||
| ncRNA |
nfkbiaa-002
(1)
|
Ensembl | 864 nt | ||
| ncRNA |
nfkbiaa-003
(1)
|
Ensembl | 838 nt |
Interactions and Pathways
No data available
Plasmids
No data available