Gene
nfkbiaa
- ID
- ZDB-GENE-040426-2227
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
- Symbol
- nfkbiaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Involved in negative regulation of hematopoietic progenitor cell differentiation and response to virus. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Is expressed in several structures, including lateral line system; periderm; pronephric duct; tail bud; and vent. Orthologous to human NFKBIA (NFKB inhibitor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85769 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia and immunodeficiency 2 | Alliance | Ectodermal dysplasia and immunodeficiency 2 | 612132 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | NF-kappa-B Inhibitor |
|---|---|---|---|---|
|
UniProtKB:F1QCG4
|
310 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfkbiaa-202
(1)
|
Ensembl | 1,344 nt | ||
| ncRNA |
nfkbiaa-002
(1)
|
Ensembl | 864 nt | ||
| ncRNA |
nfkbiaa-003
(1)
|
Ensembl | 838 nt |
Interactions and Pathways
No data available
Plasmids
No data available