Gene

epcam

ID
ZDB-GENE-040426-2209
Name
epithelial cell adhesion molecule
Symbol
epcam Nomenclature History
Previous Names
  • pan-epithelial glycoprotein (1)
  • sb:cb6
  • tacstd
  • wu:fj17g02
  • zgc:110304 (1)
  • zgc:77119
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; liver development; and posterior lateral line neuromast primordium migration. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Is expressed in several structures, including digestive system; integument; pectoral fin bud; pronephros; and sensory system. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With epcam Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital diarrhea 5 with tufting enteropathy Alliance Diarrhea 5, with tufting enteropathy, congenital 613217
hereditary nonpolyposis colorectal cancer type 8 Alliance Colorectal cancer, hereditary nonpolyposis, type 8 613244
Associated With epcam Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Family IPR043406 Transmembrane glycoprotein EPCAM/Trop-2
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length Thyroglobulin type-1 Thyroglobulin type-1 superfamily Transmembrane glycoprotein EPCAM/Trop-2
UniProtKB:Q568H0 303
UniProtKB:B8JM11 303
UniProtKB:Q6DRJ5 303
UniProtKB:Q6NY70 302
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations