ZFIN is now using GRCz12tu for Genomic Data
Gene
spint1a
- ID
- ZDB-GENE-040426-2169
- Name
- serine peptidase inhibitor, Kunitz type 1 a
- Symbol
- spint1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables peptidase inhibitor activity. Involved in regulation of inflammatory response. Acts upstream of or within several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Used to study psoriasis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb376 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 42 figures from 13 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020901 | Proteinase inhibitor I2, Kunitz, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR002223 | Pancreatic trypsin inhibitor Kunitz domain |
| Domain | IPR011106 | Seven cysteines, N-terminal |
| Domain | IPR013980 | MANSC domain |
| Domain | IPR022409 | PKD/Chitinase domain |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR035986 | PKD domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036880 | Pancreatic trypsin inhibitor Kunitz domain superfamily |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin-like fold | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | MANSC domain | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | PKD/Chitinase domain | PKD domain superfamily | Proteinase inhibitor I2, Kunitz, conserved site | Seven cysteines, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QCE4 | InterPro | 523 | |||||||||||
| UniProtKB:Q7T363 | InterPro | 516 | |||||||||||
| UniProtKB:A0A8M9P036 | InterPro | 506 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spint1a-201
(1)
|
Ensembl | 2,343 nt | ||
| mRNA |
spint1a-202
(1)
|
Ensembl | 3,726 nt | ||
| mRNA |
spint1a-203
(1)
|
Ensembl | 3,651 nt | ||
| mRNA |
spint1a-204
(1)
|
Ensembl | 3,702 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers