Gene
pla2g6
- ID
- ZDB-GENE-040426-2079
- Name
- phospholipase A2, group VI (cytosolic, calcium-independent)
- Symbol
- pla2g6 Nomenclature History
- Previous Names
-
- wu:fc06g09 (1)
- zgc:77476
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have hydrolase activity. Predicted to be involved in lipid catabolic process. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Is expressed in brain. Orthologous to human PLA2G6 (phospholipase A2 group VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Sánchez et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodegeneration with brain iron accumulation 2a | Alliance | Infantile neuroaxonal dystrophy 1 | 256600 |
| neurodegeneration with brain iron accumulation 2b | Alliance | Neurodegeneration with brain iron accumulation 2B | 610217 |
| Parkinson's disease 14 | Alliance | Parkinson disease 14, autosomal recessive | 612953 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002641 | Patatin-like phospholipase domain |
| Family | IPR047148 | 85/88 kDa calcium-independent phospholipase A2 |
| Homologous_superfamily | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | 85/88 kDa calcium-independent phospholipase A2 | Acyl transferase/acyl hydrolase/lysophospholipase | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Patatin-like phospholipase domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PV82
|
799 | |||||
|
UniProtKB:A0A8M9PRQ9
|
785 | |||||
|
UniProtKB:Q6NWY0
|
818 | |||||
|
UniProtKB:A0A8M9PJI1
|
824 | |||||
|
UniProtKB:F1QXU0
|
818 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
pla2g6-202
(1)
|
Havana | 873 nt | |
| mRNA |
pla2g6-203
(1)
|
Havana | 3830 nt | |
| mRNA |
pla2g6-204
(1)
|
Havana | 549 nt |
Interactions and Pathways
No data available
Plasmids
No data available