Gene
pla2g6
- ID
- ZDB-GENE-040426-2079
- Name
- phospholipase A2, group VI (cytosolic, calcium-independent)
- Symbol
- pla2g6 Nomenclature History
- Previous Names
-
- wu:fc06g09 (1)
- zgc:77476
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium-independent phospholipase A2 activity and palmitoyl-CoA hydrolase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and positive regulation of ceramide biosynthetic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; heart; liver; muscle; and ovary. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Sánchez et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodegeneration with brain iron accumulation 2a | Alliance | Infantile neuroaxonal dystrophy 1 | 256600 |
| neurodegeneration with brain iron accumulation 2b | Alliance | Neurodegeneration with brain iron accumulation 2B | 610217 |
| Parkinson's disease 14 | Alliance | Parkinson disease 14, autosomal recessive | 612953 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002641 | Patatin-like phospholipase domain |
| Family | IPR047148 | 85/88 kDa calcium-independent phospholipase A2 |
| Homologous_superfamily | IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | 85/88 kDa calcium-independent phospholipase A2 | Acyl transferase/acyl hydrolase/lysophospholipase | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Patatin-like phospholipase domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PV82
|
799 | |||||
|
UniProtKB:A0A8M9PRQ9
|
785 | |||||
|
UniProtKB:Q6NWY0
|
818 | |||||
|
UniProtKB:A0A8M9PJI1
|
824 | |||||
|
UniProtKB:F1QXU0
|
818 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pla2g6-201
(1)
|
Ensembl | 3,741 nt | ||
| mRNA |
pla2g6-202
(1)
|
Ensembl | 873 nt | ||
| mRNA |
pla2g6-203
(1)
|
Ensembl | 3,830 nt | ||
| mRNA |
pla2g6-204
(1)
|
Ensembl | 549 nt | ||
| mRNA |
pla2g6-205
(1)
|
Ensembl | 7,531 nt | ||
| mRNA |
pla2g6-206
(1)
|
Ensembl | 7,606 nt |
Interactions and Pathways
No data available
Plasmids
No data available