Gene

pla2g6

ID
ZDB-GENE-040426-2079
Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Symbol
pla2g6 Nomenclature History
Previous Names
  • wu:fc06g09 (1)
  • zgc:77476
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Is predicted to enable calcium-independent phospholipase A2 activity and palmitoyl-CoA hydrolase activity. Involved in cardiolipin acyl-chain remodeling and positive regulation of ceramide biosynthetic process. Acts upstream of or within lipid catabolic process. Is expressed in several structures, including eye; heart; liver; muscle; and ovary. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Sánchez et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pla2g6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neurodegeneration with brain iron accumulation 2a Alliance Infantile neuroaxonal dystrophy 1 256600
neurodegeneration with brain iron accumulation 2b Alliance Neurodegeneration with brain iron accumulation 2B 610217
Parkinson's disease 14 Alliance Parkinson disease 14, autosomal recessive 612953
Associated With pla2g6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002641 Patatin-like phospholipase domain
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Acyl transferase/acyl hydrolase/lysophospholipase Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Patatin-like phospholipase domain
UniProtKB:A0A2R8RYP7 824
UniProtKB:Q1LWA7 818
UniProtKB:H0WEI5 151
UniProtKB:H0WEP7 291
UniProtKB:Q1LWE7 210
UniProtKB:A0A286Y8H5 793
UniProtKB:H0WE43 824
UniProtKB:F1QXU0 818
UniProtKB:Q6NWY0 818
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations