Gene
uqcrfs1
- ID
- ZDB-GENE-040426-2060
- Name
- ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
- Symbol
- uqcrfs1 Nomenclature History
- Previous Names
-
- fb78f10
- wu:fb05d11
- wu:fb78f10 (1)
- wu:fj05e12
- zgc:73109
- zgc:85614
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including alar plate midbrain region; axis; hatching gland; optic tectum; and polster. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73109 (1 image)
- IMAGE:6909161 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mitochondrial complex III deficiency, nuclear type 10 | 618775 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004192 | Cytochrome b-c1 complex subunit Rieske, transmembrane domain |
| Domain | IPR005805 | Rieske iron-sulphur protein, C-terminal |
| Domain | IPR006317 | Ubiquinol-cytochrome c reductase, iron-sulphur subunit |
| Domain | IPR015248 | Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal |
| Domain | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| Family | IPR014349 | Rieske iron-sulphur protein |
| Homologous_superfamily | IPR011070 | Globular protein, non-globular alpha/beta subunit |
| Homologous_superfamily | IPR036922 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| Homologous_superfamily | IPR037008 | Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b-c1 complex subunit Rieske, transmembrane domain | Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily | Globular protein, non-globular alpha/beta subunit | Rieske [2Fe-2S] iron-sulphur domain | Rieske [2Fe-2S] iron-sulphur domain superfamily | Rieske iron-sulphur protein | Rieske iron-sulphur protein, C-terminal | Ubiquinol-cytochrome c reductase, iron-sulphur subunit | Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A7MCR1 | InterPro | 273 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
uqcrfs1-201
(1)
|
Ensembl | 3,965 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69M16 | ZFIN Curated Data | |
| Encodes | EST | fb05d11 | ZFIN Curated Data | |
| Encodes | EST | fb78f10 | ||
| Encodes | EST | fj05e12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6909161 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:73109 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85614 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174806 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001103194 (1) | 1418 nt | ||
| Genomic | GenBank:BX005081 (2) | 168607 nt | ||
| Polypeptide | UniProtKB:A7MCR1 (1) | 273 aa |
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Uszczynska-Ratajczak, B., Sugunan, S., Kwiatkowska, M., Migdal, M., Carbonell-Sala, S., Sokol, A., Winata, C.L., Chacinska, A. (2022) Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish. Life science alliance. 6(1):
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ling, X.P., Lu, Y.H., and Huang, H.Q. (2012) Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Environmental science and pollution research international. 19(9):3925-3941
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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