Gene

hk2

ID
ZDB-GENE-040426-2017
Name
hexokinase 2
Symbol
hk2 Nomenclature History
Previous Names
  • DrHXK2 (1)
  • fi09d05 (1)
  • fi17h06 (1)
  • wu:fi09d05 (1)
  • wu:fi17h06 (1)
  • wu:fi31b04
  • zgc:55926
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Predicted to be involved in cellular glucose homeostasis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and nervous system. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hk2 Human Ortholog
No data available
Associated With hk2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR019807 Hexokinase, binding site
Domain IPR022672 Hexokinase, N-terminal
Domain IPR022673 Hexokinase, C-terminal
Family IPR001312 Hexokinase
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Hexokinase Hexokinase, binding site Hexokinase, C-terminal Hexokinase, N-terminal
UniProtKB:A0A2R8PXN0 891
UniProtKB:B8JKC9 919
UniProtKB:A0A2R8QIG3 907
UniProtKB:Q7ZVL7 919
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations