Gene
asb2b
- ID
- ZDB-GENE-040426-20
- Name
- ankyrin repeat and SOCS box containing 2b
- Symbol
- asb2b Nomenclature History
- Previous Names
-
- zgc:77223
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within cardiac myofibril assembly. Is expressed in adaxial cell; brain; cardiovascular system; musculature system; and somite. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77223 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns33 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| la020221Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020222Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23198 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-asb2b | Fukuda et al., 2017 | |
| MO1-asb2b | N/A | Min et al., 2021 |
| MO2-asb2b | N/A | Min et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001496 | SOCS box domain |
| Family | IPR051165 | Multifunctional Ankyrin Repeat Domain-Containing Protein |
| Family | IPR051573 | Ankyrin repeat and SOCS box domain-containing protein |
| Homologous_superfamily | IPR036036 | SOCS box-like domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat and SOCS box domain-containing protein | Ankyrin repeat-containing domain superfamily | Multifunctional Ankyrin Repeat Domain-Containing Protein | SOCS box domain | SOCS box-like domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8U1
|
512 | ||||||
|
UniProtKB:Q6NWY5
|
563 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgFOS(asb2b:GFP-asb2b) |
|
|
| 1 | Fukuda et al., 2017 |
| TgFOS(asb2b:GFP-GAL4FF) |
|
| 1 | Fukuda et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-416D2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77223 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175040 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214725 (1) | 2211 nt | ||
| Genomic | GenBank:CU657975 (1) | 34271 nt | ||
| Polypeptide | UniProtKB:Q6NWY5 (1) | 563 aa |
- Min, K.D., Asakura, M., Shirai, M., Yamazaki, S., Ito, S., Fu, H.Y., Asanuma, H., Asano, Y., Minamino, T., Takashima, S., Kitakaze, M. (2021) ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Scientific Reports. 11:23056
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Fukuda, R., Gunawan, F., Beisaw, A., Jimenez-Amilburu, V., Maischein, H.M., Kostin, S., Kawakami, K., Stainier, D.Y. (2017) Proteolysis regulates cardiomyocyte maturation and tissue integration. Nature communications. 8:14495
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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