Gene

sucla2

ID
ZDB-GENE-040426-1963
Name
succinate-CoA ligase ADP-forming subunit beta
Symbol
sucla2 Nomenclature History
Previous Names
  • wu:fb18c11
  • wu:fj38c11
  • wu:fj90d07
  • zgc:73397
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to localize to mitochondrion and succinate-CoA ligase complex. Is expressed in several structures, including axis; hatching gland; mesoderm; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sucla2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitochondrial DNA depletion syndrome 5 Alliance Mitochondrial DNA depletion syndrome 5 (encephalomyopathic with or without methylmalonic aciduria) 612073
Associated With sucla2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
Domain IPR005811 ATP-citrate lyase/succinyl-CoA ligase
Domain IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
Family IPR005809 Succinate--CoA synthetase, beta subunit
Family IPR034723 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
Homologous_superfamily IPR016102 Succinyl-CoA synthetase-like
Domain Details Per Protein
Protein Length ATP-citrate lyase/succinyl-CoA ligase ATP-grasp fold, subdomain 1 ATP-grasp fold, succinyl-CoA synthetase-type Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Succinate--CoA synthetase, beta subunit Succinyl-CoA synthetase, beta subunit, conserved site Succinyl-CoA synthetase-like
UniProtKB:F8W590 240
UniProtKB:Q6PBI0 466
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations