Gene
sar1b
- ID
- ZDB-GENE-040426-1958
- Name
- secretion associated, Ras related GTPase 1B
- Symbol
- sar1b Nomenclature History
- Previous Names
-
- sara2
- zgc:73204
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; intestinal cholesterol absorption; and organ growth. Predicted to be located in Golgi cisterna membrane; endoplasmic reticulum; and lysosomal membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in blastomere; digestive system; nervous system; pharyngeal arch; and primary germ layer. Used to study chylomicron retention disease. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1B (secretion associated Ras related GTPase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Levic et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Levic et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chylomicron retention disease | Alliance | Chylomicron retention disease | 246700 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chylomicron retention disease | AB + MO1-sar1b | control | Levic et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase superfamily, ARF/SAR type | Small GTPase superfamily, SAR1-type | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6PBX2
|
198 |
Interactions and Pathways
No data available
Plasmids
No data available