ppib

ID

ZDB-GENE-040426-1955

Name

peptidylprolyl isomerase B (cyclophilin B)

Symbol

ppib Nomenclature History

Previous Names

cb87 (1)
sb:cb87
wu:fa97f08
zgc:73214 (1)
zgc:86796

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including axis; hatching gland; notochord; pectoral fin musculature; and polster. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Orthologous to human PPIB (peptidylprolyl isomerase B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb87 (7 images)
IMAGE:6909633 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppib Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
osteogenesis imperfecta type 9	Alliance	Osteogenesis imperfecta, type IX	259440

Associated With ppib Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Domain	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Homologous_superfamily	IPR029000	Cyclophilin-like domain superfamily