Gene
cluap1
- ID
- ZDB-GENE-040426-1943
- Name
- clusterin associated protein 1
- Symbol
- cluap1 Nomenclature History
- Previous Names
-
- fj16b11
- qil
- qilin
- unm_au5
- wu:fj16b11
- zgc:56115 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly; kidney development; and photoreceptor cell maintenance. Predicted to be located in cell projection and nucleus. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium and microtubule organizing center. Orthologous to human CLUAP1 (clusterin associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56115 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| au5 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hi3959aTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa5703 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44181 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| stl839 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cluap1 | Colijn et al., 2022 | |
| MO1-cluap1 | N/A | Aanstad et al., 2009 |
| MO2-cluap1 | N/A | Aanstad et al., 2009 |
| MO3-cluap1 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019366 | Clusterin-associated protein-1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Clusterin-associated protein-1 |
|---|---|---|---|
| UniProtKB:A0A8M9PTX5 | InterPro | 447 | |
| UniProtKB:A0A8M9P5T3 | InterPro | 447 | |
| UniProtKB:A0A8M9PXC0 | InterPro | 448 | |
| UniProtKB:Q7ZVC2 | InterPro | 427 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cluap1-202
(1)
|
Ensembl | 1,760 nt | ||
| mRNA |
cluap1-203
(1)
|
Ensembl | 823 nt | ||
| ncRNA |
cluap1-002
(1)
|
Ensembl | 832 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-203B10 | ZFIN Curated Data | |
| Contains | SNP | rs3729348 | ZFIN Curated Data | |
| Contains | SNP | rs3729349 | ZFIN Curated Data | |
| Encodes | EST | fj16b11 | ||
| Encodes | cDNA | MGC:56115 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213008 (1) | 1711 nt | ||
| Genomic | GenBank:CU571252 (1) | 118798 nt | ||
| Polypeptide | UniProtKB:A0A8M9PXC0 (1) | 448 aa |
- Colijn, S., Yin, Y., Stratman, A.N. (2022) High-throughput methodology to identify CRISPR-generated Danio rerio mutants using fragment analysis with unmodified PCR products. Developmental Biology. 484:22-29
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Soens, Z.T., Li, Y., Zhao, L., Eblimit, A., Dharmat, R., Li, Y., Chen, Y., Naqeeb, M., Fajardo, N., Lopez, I., Sun, Z., Koenekoop, R.K., Chen, R. (2016) Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genetics in medicine : official journal of the American College of Medical Genetics. 18(10):1044-51
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kallakuri, S., Yu, J.A., Li, J., Li, Y., Weinstein, B.M., Nicoli, S., Sun, Z. (2015) Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish. Journal of the American Society of Nephrology : JASN. 26(4):864-75
- Lee, C., Wallingford, J.B., Gross, J.M. (2014) cluap1 is essential for ciliogenesis and photoreceptor maintenance in the vertebrate eye. Investigative ophthalmology & visual science. 55(7):4585-92
- Lee, J., Cox, B.D., Daly, C.M., Lee, C., Nuckels, R.J., Tittle, R.K., Uribe, R.A., and Gross, J.M. (2012) An ENU Mutagenesis Screen in Zebrafish for Visual System Mutants Identifies a Novel Splice-Acceptor Site Mutation in patched2 that Results in Colobomas. Investigative ophthalmology & visual science. 53(13):8214-8221
- Li, J., and Sun, Z. (2011) Qilin is essential for cilia assembly and normal kidney development in zebrafish. PLoS One. 6(11):e27365
- Aanstad, P., Santos, N., Corbit, K.C., Scherz, P.J., Trinh, L.A., Salvenmoser, W., Huisken, J., Reiter, J.F., and Stainier, D.Y. (2009) The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling. Current biology : CB. 19(12):1034-1039
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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