Gene
slc25a3b
- ID
- ZDB-GENE-040426-1916
- Name
- solute carrier family 25 member 3b
- Symbol
- slc25a3b Nomenclature History
- Previous Names
-
- slc25a3
- wu:fb59a06
- zgc:56226
- zgc:85664
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable phosphate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to act upstream of or within mitochondrial phosphate ion transmembrane transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including digestive system; endocrine system; epidermis; nervous system; and pectoral fin. Orthologous to human SLC25A3 (solute carrier family 25 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24590 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mitochondrial phosphate carrier deficiency | 610773 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial carrier domain superfamily | Mitochondrial phosphate carrier protein SLC25A3/Pic2/Mir1-like | Mitochondrial substrate/solute carrier |
|---|---|---|---|---|---|
| UniProtKB:Q7ZV45 | InterPro | 356 | |||
| UniProtKB:A0A2R8RYH8 | InterPro | 355 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc25a3b-201
(1)
|
Ensembl | 1,443 nt | ||
| mRNA |
slc25a3b-202
(1)
|
Ensembl | 957 nt | ||
| mRNA |
slc25a3b-204
(1)
|
Ensembl | 674 nt | ||
| mRNA |
slc25a3b-205
(1)
|
Ensembl | 1,279 nt | ||
| ncRNA |
slc25a3b-002
(1)
|
Ensembl | 727 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-130N20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-267N3 | ZFIN Curated Data | |
| Encodes | EST | fb59a06 | ||
| Encodes | cDNA | MGC:56226 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85664 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213722 (1) | 1407 nt | ||
| Genomic | GenBank:CR855322 (1) | 140318 nt | ||
| Polypeptide | UniProtKB:Q7ZV45 (1) | 356 aa |
- Calvello, R., Cianciulli, A., Mitolo, V., Porro, A., Panaro, M.A. (2019) Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute Carrier Genes (Zebrafish, Chicken, Mouse and Human). Non-coding RNA. 5(1)
- Calvello, R., Cianciulli, A., Panaro, M.A. (2018) Unusual structure and splicing pattern of the vertebrate mitochondrial solute carrier SLC25A3 gene. Journal of genetics. 97:225-233
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Garcia-Reyero, N., Escalon, L., Prats, E., Faria, M., Soares, A.M., Raldúa, D. (2016) Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bulletin of environmental contamination and toxicology. 96(6):707-713
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yan, Y.L., Bhattacharya, P., He, X., Ponugoti, B., Marquardt, B., Layman, J., Grunloh, M., Postlethwait, J.H., and Rubin, D. (2012) Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. The Journal of endocrinology. 214(3):421-435
- Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G. (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Developmental Biology. 359(2):251-61
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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