Gene
tpm3
- ID
- ZDB-GENE-030826-16
- Name
- tropomyosin 3
- Symbol
- tpm3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity. Involved in skeletal myofibril assembly. Predicted to localize to actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77592 (21 images)
- cb674 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Bonnet et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myopathy 4A | Alliance | Congenital myopathy 4A, autosomal dominant | 255310 |
| nemaline myopathy 1 | Alliance | Congenital myopathy 4B, autosomal recessive | 609284 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|
|
UniProtKB:A0A8M2B6C5
|
248 | ||
|
UniProtKB:A0A8M2B602
|
284 | ||
|
UniProtKB:A0A2R8Q650
|
284 | ||
|
UniProtKB:A0A8M2B695
|
248 | ||
|
UniProtKB:I3ISQ1
|
284 | ||
|
UniProtKB:Q6P0W3
|
284 | ||
|
UniProtKB:Q803M1
|
248 |
Interactions and Pathways
No data available
Plasmids
No data available