Gene

bace1

ID
ZDB-GENE-040426-1835
Name
beta-secretase 1
Symbol
bace1 Nomenclature History
Previous Names
  • zgc:77409
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have aspartic-type endopeptidase activity. Involved in myelination in peripheral nervous system and positive regulation of myelination. Predicted to localize to several cellular components, including endosome; lysosome; and membrane raft. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from van Bebber et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bace1 Human Ortholog
No data available
Associated With bace1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001969 Aspartic peptidase, active site
Domain IPR033121 Peptidase family A1 domain
Domain IPR033874 Memapsin-like
Family IPR001461 Aspartic peptidase A1 family
Family IPR009119 Beta-secretase BACE
Family IPR009120 Beta-secretase BACE1
Homologous_superfamily IPR021109 Aspartic peptidase domain superfamily
Domain Details Per Protein
Protein Length Aspartic peptidase A1 family Aspartic peptidase, active site Aspartic peptidase domain superfamily Beta-secretase BACE Beta-secretase BACE1 Memapsin-like Peptidase family A1 domain
UniProtKB:Q6NZT7 505
UniProtKB:A0A0G2KH37 221
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations