bace1

ID

ZDB-GENE-040426-1835

Name

beta-secretase 1

Symbol

bace1 Nomenclature History

Previous Names

zgc:77409

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within myelination in peripheral nervous system and positive regulation of myelination. Predicted to be located in several cellular components, including cytoplasmic vesicle; lysosome; and membrane raft. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from van Bebber et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bace1 Human Ortholog

No data available

Associated With bace1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001969	Aspartic peptidase, active site
Domain	IPR033121	Peptidase family A1 domain
Domain	IPR033874	Memapsin-like
Family	IPR001461	Aspartic peptidase A1
Family	IPR009119	Beta-secretase BACE
Family	IPR009120	Beta-secretase BACE1
Homologous_superfamily	IPR021109	Aspartic peptidase domain superfamily