Gene
ca7
- ID
- ZDB-GENE-040426-1786
- Name
- carbonic anhydrase VII
- Symbol
- ca7 Nomenclature History
- Previous Names
-
- zgc:73385
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable carbonate dehydratase activity. Predicted to be involved in regulation of intracellular pH. Predicted to be active in cytoplasm. Is expressed in brain; musculature system; presumptive segmental plate; retina; and somite. Orthologous to human CA7 (carbonic anhydrase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73385 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018338 | Carbonic anhydrase, alpha-class, conserved site |
| Domain | IPR001148 | Alpha carbonic anhydrase domain |
| Family | IPR023561 | Carbonic anhydrase, alpha-class |
| Family | IPR041890 | Carbonic anhydrase VII |
| Homologous_superfamily | IPR036398 | Alpha carbonic anhydrase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha carbonic anhydrase domain | Alpha carbonic anhydrase domain superfamily | Carbonic anhydrase, alpha-class | Carbonic anhydrase, alpha-class, conserved site | Carbonic anhydrase VII |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PBI7 | InterPro | 263 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-71E3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-121H18 | ||
| Encodes | cDNA | MGC:73385 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174490 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198139 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198143 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200813 (1) | 1789 nt | ||
| Genomic | GenBank:BX511136 (1) | 187217 nt | ||
| Polypeptide | UniProtKB:Q6PBI7 (1) | 263 aa |
- Matsumoto, H., Fujiwara, S., Miyagi, H., Nakamura, N., Shiga, Y., Ohta, T., Tsuzuki, M. (2017) Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Marine biotechnology (New York, N.Y.). 19(5):430-440
- Tarbashevich, K., Reichman-Fried, M., Grimaldi, C., Raz, E. (2015) Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Current biology : CB. 25(8):1096-103
- Ito, Y., Kobayashi, S., Nakamura, N., Miyagi, H., Esaki, M., Hoshijima, K., and Hirose, S. (2013) Close Association of Carbonic Anhydrase (CA2a and CA15a), Na(+)/H(+) Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in Zebrafish Ionocytes Responsible for Na(+) Uptake. Frontiers in Physiology. 4:59
- Esbaugh, A.J., Perry, S.F., and Gilmour, K.M. (2009) Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio. American journal of physiology. Regulatory, integrative and comparative physiology. 296(1):R150-R160
- Lin, T.Y., Liao, B.K., Horng, J.L., Yan, J.J., Hsiao, C.D., and Hwang, P.P. (2008) Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 294(5):C1250-C1260
- O'Boyle, S., Bree, R.T., McLoughlin, S., Grealy, M., and Byrnes, L. (2007) Identification of zygotic genes expressed at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 358(2):462-468
- Leung, Y.F., and Dowling, J.E. (2005) Gene Expression Profiling of Zebrafish Embryonic Retina. Zebrafish. 2(4):269-283
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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