Gene

gnao1a

ID
ZDB-GENE-040426-1757
Name
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
Symbol
gnao1a Nomenclature History
Previous Names
  • gnao1
  • Galpha o1 (1)
  • wu:fq26h05
  • zgc:73315
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in gill; nervous system; neural rod; and trigeminal placode. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 17. Orthologous to human GNAO1 (G protein subunit alpha o1).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnao1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 17 Alliance Epileptic encephalopathy, early infantile, 17 615473
Neurodevelopmental disorder with involuntary movements 617493
Associated With gnao1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
Family IPR001408 G-protein alpha subunit, group I
Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length G-protein alpha subunit, group I G protein alpha subunit, helical insertion Guanine nucleotide binding protein (G-protein), alpha subunit P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F8W442 354
UniProtKB:Q6PBP1 354
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations