Gene
gnao1a
- ID
- ZDB-GENE-040426-1757
- Name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
- Symbol
- gnao1a Nomenclature History
- Previous Names
-
- gnao1
- Galpha o1 (1)
- wu:fq26h05
- zgc:73315
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled serotonin receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 17. Is expressed in gill; nervous system; neural rod; and trigeminal placode. Orthologous to human GNAO1 (G protein subunit alpha o1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu90 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 17 | Alliance | Developmental and epileptic encephalopathy 17 | 615473 |
| neurodevelopmental disorder with involuntary movements | Alliance | Neurodevelopmental disorder with involuntary movements | 617493 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Family | IPR001408 | G-protein alpha subunit, group I |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | G-protein alpha subunit, group I | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:Q6PBP1
|
354 | ||||
|
UniProtKB:A0A8M2B604
|
311 | ||||
|
UniProtKB:F8W442
|
354 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gnao1a-201
(1)
|
Ensembl | 2,401 nt | ||
| mRNA |
gnao1a-202
(1)
|
Ensembl | 1,089 nt |
Interactions and Pathways
No data available
Plasmids
No data available