Gene
pcmtl
- ID
- ZDB-GENE-040426-1738
- Name
- l-isoaspartyl protein carboxyl methyltransferase, like
- Symbol
- pcmtl Nomenclature History
- Previous Names
-
- zgc:73268
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within regulation of calcium-mediated signaling. Predicted to be active in cytoplasm. Is expressed in brain; heart; liver; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73268 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pcmtl | N/A | Soliman et al., 2021 |
| MO2-pcmtl | N/A | Soliman et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|
|
UniProtKB:F1QL05
|
249 | ||
|
UniProtKB:A0A8M2B570
|
257 | ||
|
UniProtKB:Q6PBS7
|
228 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210H14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73268 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200768 (1) | 1434 nt | ||
| Genomic | GenBank:BX649281 (2) | 157279 nt | ||
| Polypeptide | UniProtKB:A0A8M2B570 (1) | 257 aa |
No data available
- Soliman, R., Cordero-Maldonado, M.L., Martins, T.G., Moein, M., Conrotte, J.F., Warmack, R.A., Skupin, A., Crawford, A.D., Clarke, S.G., Linster, C.L. (2021) l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Frontiers in genetics. 11:612343
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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