Gene
arhgap12b
- ID
- ZDB-GENE-040426-1727
- Name
- Rho GTPase activating protein 12b
- Symbol
- arhgap12b Nomenclature History
- Previous Names
-
- arhgap12
- zgc:73239 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in retina and somite. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151471 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38897 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001202 | WW domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR035491 | ARHGAP12, SH3 domain |
| Family | IPR050729 | Rho GTPase-activating protein |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ARHGAP12, SH3 domain | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating protein | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IKK1 | InterPro | 841 | ||||||||||
| UniProtKB:A0A8M9QME4 | InterPro | 882 | ||||||||||
| UniProtKB:A0A8M9QIL2 | InterPro | 881 | ||||||||||
| UniProtKB:A0A8M9QE56 | InterPro | 458 | ||||||||||
| UniProtKB:A0A8M9Q893 | InterPro | 664 | ||||||||||
| UniProtKB:Q6P4P5 | InterPro | 817 | ||||||||||
| UniProtKB:A0A8M9PW53 | InterPro | 858 | ||||||||||
| UniProtKB:A0AB32U447 | InterPro | 882 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap12b-201
(1)
|
Ensembl | 4,227 nt | ||
| mRNA |
arhgap12b-202
(1)
|
Ensembl | 831 nt | ||
| mRNA |
arhgap12b-203
(1)
|
Ensembl | 463 nt | ||
| mRNA |
arhgap12b-204
(1)
|
Ensembl | 4,670 nt | ||
| mRNA |
arhgap12b-205
(1)
|
Ensembl | 4,617 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-148D16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7151471 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:73239 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200874 (1) | 4200 nt | ||
| Genomic | GenBank:BX470098 (1) | 249826 nt | ||
| Polypeptide | UniProtKB:A0A8M9QME4 (1) | 882 aa |
- Yin, J., McLoughlin, S., Jeffery, I.B., Glaviano, A., Kennedy, B., and Higgins, D.G. (2010) Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data. BMC Genomics. 11:50
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 2 of 2
Show