ZFIN ID: ZDB-GENE-040426-1726
Gene Name: ubiquinol-cytochrome c reductase complex assembly factor 2
Gene Symbol: uqcc2    Nomenclature History

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Previous Name: zgc:73238

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to be involved in several processes, including mitochondrial respiratory chain complex III assembly; positive regulation of cellular protein metabolic process; and regulation of insulin secretion. Predicted to localize to the mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial nucleoid. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 7. Is expressed in intestinal bulb; intestinal bulb primordium; liver; and pectoral fin musculature. Orthologous to human UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2).
Genome Resources: Alliance (1),  Gene:393731 (1),  Ensembl(GRCz11):ENSDARG00000011272 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:73238]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9189 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH uqcc2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mitochondrial complex III deficiency nuclear type 7 Alliance Mitochondrial complex III deficiency, nuclear type 7 615824
    DISEASE ASSOCIATED WITH uqcc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitochondrial respiratory chain complex III assembly (more)
    Cellular Component mitochondrial inner membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR037698 Ubiquinol-cytochrome-c reductase complex assembly factor 2
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA uqcc2-201 (1)    Ensembl 711
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM uqcc2 No data available
    MARKER RELATIONSHIPS
    uqcc2 Contained in: [BAC] CH73-15B2 (1)
    uqcc2 Encodes: [cDNA] MGC:73238 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200758 (1) 729 nt
    Genomic GenBank:CU463231 (1) 104010 nt
    Select Tool
    Polypeptide UniProtKB:Q6PBU7 (1) 129 aa
    Sequence Information (all 12)
    ORTHOLOGY for uqcc2 ( Chr: 6 )
    CITATIONS (20)