Gene

gnb5b

ID

ZDB-GENE-040426-1712

Name

guanine nucleotide binding protein (G protein), beta 5b

Symbol

gnb5b Nomenclature History

Previous Names

gnb5
zgc:73196

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to be involved in signal transduction. Predicted to localize to membrane. Is expressed in cardiovascular system; cranial ganglion; neurons; and visual system. Orthologous to human GNB5 (G protein subunit beta 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73196 (8 images)
IMAGE:6906816 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnb5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual developmental disorder with cardiac arrhythmia	Alliance	Lodder-Merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	617173
		Lodder-Merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	617182

Associated With gnb5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001632	G-protein, beta subunit
Family	IPR016346	Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat