Gene

becn1

ID
ZDB-GENE-040426-1666
Name
beclin 1, autophagy related
Symbol
becn1 Nomenclature History
Previous Names
  • zgc:73097
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Involved in several processes, including autophagy; cellular senescence; and regulation of skeletal muscle tissue regeneration. Predicted to localize to phagophore assembly site; phosphatidylinositol 3-kinase complex, class III, type I; and phosphatidylinositol 3-kinase complex, class III, type II. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is expressed in brain; intestine; liver; and muscle. Orthologous to several human genes including BECN1 (beclin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With becn1 Human Ortholog
No data available
Associated With becn1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR029318 Beclin-1, BH3 domain
Domain IPR040455 Atg6, BARA domain
Domain IPR041691 Atg6/beclin, coiled-coil domain
Family IPR007243 Atg6/Beclin
Family IPR032913 Beclin-1
Homologous_superfamily IPR038274 Atg6/Beclin C-terminal domain superfamily
Domain Details Per Protein
Protein Length Atg6, BARA domain Atg6/Beclin Atg6/beclin, coiled-coil domain Atg6/Beclin C-terminal domain superfamily Beclin-1 Beclin-1, BH3 domain
UniProtKB:F1Q7V0 333
UniProtKB:F1RCP1 447
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-becn1 polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations