Gene

upf3b

ID
ZDB-GENE-040426-1630
Name
UPF3B regulator of nonsense mediated mRNA decay
Symbol
upf3b Nomenclature History
Previous Names
  • zgc:174674
  • zgc:66390
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of translation. Predicted to localize to cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 82 and syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ma et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With upf3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic X-linked intellectual disability 14 Alliance Mental retardation, X-linked, syndromic 14 300676
Associated With upf3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005120 UPF3 domain
Family IPR039722 Nonsense-mediated mRNA decay protein 3
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Domain Details Per Protein
Protein Length Nonsense-mediated mRNA decay protein 3 Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily UPF3 domain
UniProtKB:F1QNX7 467
UniProtKB:Q7SXF0 467
UniProtKB:A0A2R8QRF9 431
UniProtKB:A7MCN9 83
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations