Gene
nae1
- ID
- ZDB-GENE-040426-1552
- Name
- nedd8 activating enzyme E1 subunit 1
- Symbol
- nae1 Nomenclature History
- Previous Names
-
- appbp1
- zgc:66148
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-like modifier activating enzyme activity. Predicted to contribute to NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with dysmorphic facies and ischiopubic hypoplasia | 620210 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NEDD8-activating enzyme E1 regulatory subunit APP-BP1 | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold |
|---|---|---|---|---|---|
| UniProtKB:Q7SXP2 | InterPro | 533 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available