Gene
pdhx
- ID
- ZDB-GENE-040426-1539
- Name
- pyruvate dehydrogenase complex component X
- Symbol
- pdhx Nomenclature History
- Previous Names
-
- zgc:66110
- zgc:85977 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have transferase activity, transferring acyl groups. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHX (pyruvate dehydrogenase complex component X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85977 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate decarboxylase deficiency | Alliance | Lacticacidemia due to PDX1 deficiency | 245349 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| Domain | IPR004167 | Peripheral subunit-binding domain |
| Family | IPR045257 | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR036625 | E3-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 2-oxo acid dehydrogenase, lipoyl-binding site | Biotin/lipoyl attachment | Chloramphenicol acetyltransferase-like domain superfamily | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component | E3-binding domain superfamily | Peripheral subunit-binding domain | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI02
|
490 | ||||||||
|
UniProtKB:F1R0J8
|
496 |
Interactions and Pathways
No data available
Plasmids
No data available