Gene

pdhx

ID

ZDB-GENE-040426-1539

Name

pyruvate dehydrogenase complex component X

Symbol

pdhx Nomenclature History

Previous Names

zgc:66110
zgc:85977 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have transferase activity, transferring acyl groups. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHX (pyruvate dehydrogenase complex component X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:85977 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdhx Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pyruvate decarboxylase deficiency	Alliance	Lacticacidemia due to PDX1 deficiency	245349

Associated With pdhx Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site
Domain	IPR000089	Biotin/lipoyl attachment
Domain	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain
Domain	IPR004167	Peripheral subunit-binding domain
Family	IPR045257	Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component
Homologous_superfamily	IPR011053	Single hybrid motif
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily
Homologous_superfamily	IPR036625	E3-binding domain superfamily

Domain Details Per Protein

Protein	Length	2-oxoacid dehydrogenase acyltransferase, catalytic domain	2-oxo acid dehydrogenase, lipoyl-binding site	Biotin/lipoyl attachment	Chloramphenicol acetyltransferase-like domain superfamily	Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component	E3-binding domain superfamily	Peripheral subunit-binding domain	Single hybrid motif
UniProtKB:A0A8M2BI02 InterPro	490
UniProtKB:F1R0J8 InterPro	496

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pdhx-201 (1) Ensembl	Havana	1822 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pdhx-202 (1) Ensembl	Havana	1812 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pdhx-003 (1) Ensembl	Havana	638 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations