Gene
cyba
- ID
- ZDB-GENE-040426-1526
- Name
- cytochrome b-245, alpha polypeptide
- Symbol
- cyba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity; metal ion binding activity; and oxidoreductase activity. Acts upstream of or within macrophage chemotaxis and neutrophil migration. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66077 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Schoen et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive chronic granulomatous disease 4 | Alliance | Chronic granulomatous disease 4, autosomal recessive | 233690 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Schoen et al., 2019 |
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Bastos et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007732 | Cytochrome b558 alpha-subunit |
Domain Details Per Protein
| Protein | Length | Cytochrome b558 alpha-subunit |
|---|---|---|
|
UniProtKB:Q6PH62
|
185 |
Interactions and Pathways
No data available
Plasmids
No data available