Gene
cyba
- ID
- ZDB-GENE-040426-1526
- Name
- cytochrome b-245, alpha polypeptide
- Symbol
- cyba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity; metal ion binding activity; and oxidoreductase activity. Acts upstream of or within macrophage chemotaxis and neutrophil migration. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66077 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Schoen et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11798 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11994 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43128 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43129 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umc403 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyba | Forn-Cuní et al., 2022 | |
| CRISPR2-cyba | Forn-Cuní et al., 2022 | |
| CRISPR3-cyba | Forn-Cuní et al., 2022 | |
| CRISPR4-cyba | (2) | |
| MO1-cyba | N/A | (9) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive chronic granulomatous disease 4 | Alliance | Chronic granulomatous disease 4, autosomal recessive | 233690 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Schoen et al., 2019 |
| chronic granulomatous disease | cybasa11798/sa11798 | standard conditions | Bastos et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007732 | Cytochrome b558 alpha-subunit |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b558 alpha-subunit |
|---|---|---|---|
| UniProtKB:Q6PH62 | InterPro | 185 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mpx:cyba-GFP) |
|
| 1 | Schoen et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220F20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66077 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200579 (1) | 1115 nt | ||
| Genomic | GenBank:CR936382 (1) | 78500 nt | ||
| Polypeptide | UniProtKB:Q6PH62 (1) | 185 aa |
- Zhao, L., Wang, L.F., Wang, Y.C., Liu, A., Xiao, Q.W., Hu, M.C., Sun, M.Z., Hao, H.Y., Gao, Q., Zhao, X., Chen, D.Y. (2024) Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish. Cell biology and toxicology. 40:3636
- Chopra, K., Folkmanaitė, M., Stockdale, L., Shathish, V., Ishibashi, S., Bergin, R., Amich, J., Amaya, E. (2023) Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish. iScience. 26:106147106147
- Schoen, T.J., Calise, D.G., Bok, J.W., Giese, M.A., Nwagwu, C.D., Zarnowski, R., Andes, D., Huttenlocher, A., Keller, N.P. (2023) Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection. PLoS pathogens. 19:e1011152e1011152
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Forn-Cuní, G., Welvaarts, L., Stel, F.M., van den Hondel, C.J., Arentshorst, M., Ram, A., Meijer, A.H. (2022) Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis. Autophagy. 19(1):324-337
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Bastos, R.W., Valero, C., Silva, L.P., Schoen, T., Drott, M., Brauer, V., Silva-Rocha, R., Lind, A., Steenwyk, J.L., Rokas, A., Rodrigues, F., Resendiz-Sharpe, A., Lagrou, K., Marcet-Houben, M., Gabaldón, T., McDonnell, E., Reid, I., Tsang, A., Oakley, B.R., Loures, F.V., Almeida, F., Huttenlocher, A., Keller, N.P., Ries, L.N.A., Goldman, G.H. (2020) Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 5(2):
- Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902
- Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812
- Schoen, T.J., Rosowski, E.E., Knox, B.P., Bennin, D., Keller, N.P., Huttenlocher, A. (2019) Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Journal of Cell Science. 133(5):
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