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Gene

cyba

ID
ZDB-GENE-040426-1526
Name
cytochrome b-245, alpha polypeptide
Symbol
cyba Nomenclature History
Previous Names
  • P22phox (1)
  • zgc:66077 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable heme binding activity; metal ion binding activity; and oxidoreductase activity. Acts upstream of or within macrophage chemotaxis and neutrophil migration. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive chronic granulomatous disease cytochrome b-negative Alliance Chronic granulomatous disease 4, autosomal recessive 233690
Associated With cyba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007732 Cytochrome b558 alpha-subunit
Domain Details Per Protein
Protein Length Cytochrome b558 alpha-subunit
UniProtKB:Q6PH62 185
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations