Gene
gadd45aa
- ID
- ZDB-GENE-040426-1501
- Name
- growth arrest and DNA-damage-inducible, alpha, a
- Symbol
- gadd45aa Nomenclature History
- Previous Names
-
- gadd45al
- zgc:65993
- zgc:77480 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Acts upstream of or within paraxial mesoderm development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; endoderm; eye; otic placode; and solid lens vesicle. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65993 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023410Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1122 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gadd45aa | N/A | (2) |
| MO2-gadd45aa | N/A | Wan et al., 2011 |
| MO3-gadd45aa | N/A | Zhao et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Growth arrest and DNA damage-inducible protein GADD45 | Ribosomal protein eL30-like superfamily | Ribosomal protein eL8/eL30/eS12/Gadd45 |
|---|---|---|---|---|---|
| UniProtKB:F1R8Z0 | InterPro | 157 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gadd45aa-201
(1)
|
Ensembl | 1,253 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-171B9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65993 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77480 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200576 (1) | 1231 nt | ||
| Genomic | GenBank:CU693482 (2) | 76766 nt | ||
| Polypeptide | UniProtKB:F1R8Z0 (1) | 157 aa |
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Accogli, A., Lin, S.J., Severino, M., Kim, S.H., Huang, K., Rocca, C., Landsverk, M., Zaki, M., Al-Maawali, A., Srinivasan, V.M., Al-Thihli, K., Schaefer, G.B., Davis, M., Tonduti, D., Doneda, C., Marten, L.M., Mühlhausen, C., Gomez, M., Lamantea, E., Mena, R., Nizon, M., Procaccio, V., Begtrup, A., Telegrafi, A., Cui, H., Schulz, H.L., Mohr, J., Biskup, S., Loos, M.A., Aráoz, H.V., Salpietro, V., Keppen, L.D., Chitre, M., Petree, C., Raymond, L., Vogt, J., Swayer, L.B., Basinger, A.A., Pedersen, S.V., Pearson, T.S., Grange, D.K., Lingapp, L., McDunnah, P., Horvath, R., Cogne, B., Isidor, B., Hahn, A., Gripp, K., Jafarnejad, S.M., Ostergaard, E., Prada, C.E., Ghezzi, D., Gowda, V.K., Taylor, R.W., Sonenberg, N., Houlden, H., Sissler, M., Varshney, G.K., Maroofian, R. (2023) Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 25(11):100938
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Yang, S., Cao, S., Xu, X., Li, Q., Li, J., Guo, J., Wang, F., Bao, Y., Jiang, Z., Zhang, T., Wang, L., Sun, S. (2023) adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. iScience. 26:107516107516
- Zhu, W., Shi, Y., Zhang, C., Peng, Y., Wan, Y., Xu, Y., Liu, X., Han, B., Zhao, S., Kuang, Y., Song, H., Qiao, J. (2023) In-frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance. Clinical and translational medicine. 13:e1007e1007
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
- Yang, S., Ning, G., Hou, Y., Cao, Y., Xu, J., Wu, J., Zhang, T., Wang, Q. (2022) Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. iScience. 25:104495
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